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Keytruda (Pembrolizumab) – Advanced Immunotherapy for Multiple Cancers

What is Keytruda (Pembrolizumab)?

Keytruda, also known by its generic name Pembrolizumab, is a prescription immunotherapy drug used to treat a variety of advanced cancers. It belongs to a class of medications known as immune checkpoint inhibitors, specifically targeting the PD-1/PD-L1 pathway.

Unlike traditional chemotherapy, Keytruda activates the body’s immune system to recognize and destroy cancer cells. It is widely used in both monotherapy and combination therapy for eligible patients.

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How Does Keytruda Work?

Keytruda (Pembrolizumab) blocks the programmed death receptor-1 (PD-1) on T-cells, preventing cancer cells from hiding from the immune system. As a result, the immune system can better identify and attack tumor cells.

This innovative mechanism makes it especially effective in cancers with high PD-L1 expression, microsatellite instability-high (MSI-H) status, or tumor mutational burden-high (TMB-H).

🔬 Did you know? Keytruda was the first cancer treatment approved by the FDA based on a tumor’s genetic features rather than its location in the body.

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Keytruda is Approved to Treat the Following Cancers:

• Non-small cell lung cancer (NSCLC)

• Melanoma (skin cancer)

• Head and neck squamous cell carcinoma (HNSCC)

• Classical Hodgkin lymphoma

• Bladder cancer (urothelial carcinoma)

• Kidney cancer (renal cell carcinoma)

• Triple-negative breast cancer (TNBC)

• Cervical cancer

• Gastric and esophageal cancers

• Colorectal cancer (MSI-H or dMMR)

• Hepatocellular carcinoma (HCC)

• Endometrial cancer

Furthermore, Keytruda is indicated for tumors with MSI-H, dMMR, or TMB-H, regardless of the cancer’s tissue of origin—a true tumor-agnostic therapy.

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Benefits of Keytruda (Pembrolizumab)

Choosing Keytruda offers several powerful advantages:

• ✅ Enhances the body’s natural immune response to fight cancer

• ✅ Approved for over 15 types of cancers

• ✅ Often used as first-line therapy in advanced cancers

• ✅ Can be combined with chemotherapy, targeted therapy, or radiation

• ✅ Well-tolerated compared to traditional chemotherapy in many cases

• ✅ Offers durable responses and improved survival in eligible patients

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How is Keytruda Administered?

Keytruda is given as an intravenous (IV) infusion, typically in a hospital or cancer treatment center.

Common Dosing:

• 200 mg every 3 weeks or

• 400 mg every 6 weeks, depending on the indication and treatment plan

Each infusion usually takes 30 minutes, and your oncologist will determine the optimal duration of treatment based on your response and overall health.

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Possible Side Effects of Keytruda

Like all immunotherapies, Keytruda may cause side effects, some of which can be serious or life-threatening if not treated promptly.

Common side effects:

• Fatigue

• Rash or itching

• Diarrhea

• Cough

• Nausea

Serious immune-related side effects:

• Inflammation of the lungs (pneumonitis)

• Colitis (intestinal inflammation)

• Hepatitis (liver inflammation)

• Endocrine disorders (thyroid, pituitary, adrenal)

• Nephritis (kidney inflammation)

⚠️ Always inform your doctor if you experience new or worsening symptoms. Early management of side effects is critical for continued treatment success.

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Who Should Not Take Keytruda?

Keytruda is not suitable for everyone. It may not be recommended for:

• Patients with active autoimmune diseases

• Organ transplant recipients

• Pregnant or breastfeeding women

• Individuals with severe allergic reactions to pembrolizumab

A complete medical evaluation is required to determine eligibility.

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Keytruda vs. Chemotherapy: What’s the Difference?

While chemotherapy attacks all rapidly dividing cells, Keytruda works by stimulating your immune system to target only cancer cells. This targeted approach often results in:

• Fewer side effects

• Longer-lasting responses

• Improved quality of life during treatment

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Frequently Asked Questions About Keytruda

Is Keytruda a cure for cancer?

Keytruda is not a cure, but it has shown long-term survival benefits in many cancers. Some patients achieve complete or partial responses lasting years.

How long can you stay on Keytruda?

Patients may remain on Keytruda for up to 2 years or longer, depending on their response and tolerance.

Is Keytruda covered by insurance?

Yes, in most cases. Keytruda is FDA-approved, and many insurance plans, including Medicare, cover its cost for approved indications.

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Conclusion: Keytruda (Pembrolizumab) – A Breakthrough in Cancer Immunotherapy

If you or a loved one is facing an advanced cancer diagnosis, Keytruda (Pembrolizumab) may offer a life-extending and potentially life-saving option. Its ability to harness the immune system and deliver lasting results makes it one of the most transformative cancer therapies available today.

✅ Talk to your oncologist about whether Keytruda is right for your treatment plan.